Joesmvg

EPH receptor A2
PDB prikaz baziran na 1mqb.
Dostupne strukture
1MQB, 2E8N, 2K9Y, 2KSO, 2X10, 2X11, 3C8X, 3CZU, 3FL7, 3HEI, 3HPN, 3KKA, 3MBW, 3MX0, 3SKJ, 4P2K, 4P2W, 4PDO
Identifikatori
Simboli	EPHA2; ARCC2; CTPA; CTPP1; CTRCT6; ECK
Vanjski ID	OMIM: 176946 MGI: 95278 HomoloGene: 20929 GeneCards: EPHA2 Gene
EC broj	2.7.10.1
Ontologija gena Molekulska funkcija • aktivnost transmembranske receptorske proteinske tirozinske kinaze • aktivnost efrinskog receptora • proteinsko vezivanje Ćelijska komponenta • ćelijska membrana • integralna komponenta ćelijske membrane • fokalna adhezija Biološki proces • razviće skeletalnog sistema • angiogeneza • vaskulogeneza
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	1969	13836
Ensembl	ENSG00000142627	ENSMUSG00000006445
UniProt	P29317	Q03145
Ref. Sekv. (iRNK)	NM_004431	NM_010139
Ref. Sekv. (protein)	NP_004422	NP_034269
Lokacija (UCSC)	Chr 1: 16.45 - 16.48 Mb	Chr 4: 141.3 - 141.33 Mb
PubMed pretraga	[1]	[2]

EPH receptor A2 (efrinski receptor 2 tipa A) protein je koji je kod ljudi kodiran EPHA2 genom.^[1][2]

Ovaj gen je pripadnik grupe efrinskih receptora iz familije proteinskih turozinskih kinaza. EPH i EPH-srodni receptori uzimaju učešća u posredovanju događaja razvića, posebno u nervnom sistemu. Receptori EPH podfamilije tipično imaju jedan kinazni domen, ekstracelularni region koji sadrži domen bogat cisteinom i dva ponavljanja fibronektinskog tipa III. Efrinski receptori se dele u dve grupe na bazi sličnosti sekvenci njihovih ekstracelularnih domena i njihovih afiniteta vezivanja liganda efrina A i efrina B.^[2]

Interakcije[uredi - уреди | uredi izvor]

EPH receptor A2 formira interakcije sa PIK3R1,^[3] Grb2,^[4] ACP1^[5] i SHC1.^[4]

Reference[uredi - уреди | uredi izvor]

Literatura[uredi - уреди | uredi izvor]

• Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development.". Annu. Rev. Neurosci. 21: 309–45. PMID 9530499. doi:10.1146/annurev.neuro.21.1.309. 
• Zhou R (1998). "The Eph family receptors and ligands.". Pharmacol. Ther. 77 (3): 151–81. PMID 9576626. doi:10.1016/S0163-7258(97)00112-5. 
• Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis.". Development 126 (10): 2033–44. PMID 10207129. 
• Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly.". Int. Rev. Cytol. 196: 177–244. PMID 10730216. doi:10.1016/S0074-7696(00)96005-4. 
• Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning.". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993–1002. PMC 1692797. PMID 11128993. doi:10.1098/rstb.2000.0635. 
• Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development.". Nat. Rev. Neurosci. 2 (3): 155–64. PMID 11256076. doi:10.1038/35058515. 
• Kinch MS, Carles-Kinch K (2003). "Overexpression and functional alterations of the EphA2 tyrosine kinase in cancer.". Clin. Exp. Metastasis 20 (1): 59–68. PMID 12650608. doi:10.1023/A:1022546620495. 
• Walker-Daniels J, Hess AR, Hendrix MJ, Kinch MS (2003). "Differential regulation of EphA2 in normal and malignant cells.". Am. J. Pathol. 162 (4): 1037–42. PMC 1851246. PMID 12651595. doi:10.1016/S0002-9440(10)63899-0. 
• Lindberg RA, Hunter T (1991). "cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases". Mol. Cell. Biol. 10 (12): 6316–24. PMC 362907. PMID 2174105. 
• Pandey A, Shao H, Marks RM et al. (1995). "Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-alpha-induced angiogenesis". Science 268 (5210): 567–9. PMID 7536959. doi:10.1126/science.7536959.  CS1 održavanje: Eksplicitna upotreba et al. (link)
• Pandey A, Duan H, Dixit VM (1995). "Characterization of a novel Src-like adapter protein that associates with the Eck receptor tyrosine kinase". J. Biol. Chem. 270 (33): 19201–4. PMID 7543898. doi:10.1074/jbc.270.33.19201. 
• Ruiz JC, Robertson EJ (1994). "The expression of the receptor-protein tyrosine kinase gene, eck, is highly restricted during early mouse development". Mech. Dev. 46 (2): 87–100. PMID 7918100. doi:10.1016/0925-4773(94)90078-7. 
• Davis S, Gale NW, Aldrich TH et al. (1994). "Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity". Science 266 (5186): 816–9. PMID 7973638. doi:10.1126/science.7973638.  CS1 održavanje: Eksplicitna upotreba et al. (link)
• Pandey A, Lazar DF, Saltiel AR, Dixit VM (1994). "Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity". J. Biol. Chem. 269 (48): 30154–7. PMID 7982920. 
• Ganju P, Shigemoto K, Brennan J et al. (1994). "The Eck receptor tyrosine kinase is implicated in pattern formation during gastrulation, hindbrain segmentation and limb development". Oncogene 9 (6): 1613–24. PMID 8183555.  CS1 održavanje: Eksplicitna upotreba et al. (link)
• Gale NW, Holland SJ, Valenzuela DM et al. (1996). "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis". Neuron 17 (1): 9–19. PMID 8755474. doi:10.1016/S0896-6273(00)80276-7.  CS1 održavanje: Eksplicitna upotreba et al. (link)
• Kozlosky CJ, VandenBos T, Park L et al. (1997). "LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain". Cytokine 9 (8): 540–9. PMID 9245480. doi:10.1006/cyto.1997.0199.  CS1 održavanje: Eksplicitna upotreba et al. (link)
• Ephnomenclaturecommittee, (1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee". Cell 90 (3): 403–4. PMID 9267020. doi:10.1016/S0092-8674(00)80500-0. 

v r u PDB Galerija 1mqb: Kristalna struktura efrinske A2 (ephA2) receptorske proteinske kinaze